Publications
Kaicheng U*, Sophia Meixuan Zhang*, Ziyu Yu*, Zechuan Zhang, Jianwei Zhang, Chang He, Anbang Liu, Rui Chen, Stella Wang, Lijie Yan, Shichao Ding, Lavonda Li, Zongxin Yang, Gao Xiao, Xushuai Zhang, Kaige Bao, Haohan Wang, Athanasios V. Vasilakos, Junhan Zhao†, Siwei Chen†, Xingcai Zhang†
2024
Nature Neuroscience
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
Epi25 Collaborative (Siwei Chen, first author)
Siwei Chen*†, Laurent C Francioli*, Julia K Goodrich, Ryan L Collins, Masahiro Kanai, Qingbo Wang, Jessica Alföldi, Nicholas A Watts, Christopher Vittal, Laura D Gauthier, Timothy Poterba, Michael W Wilson, Yekaterina Tarasova, William Phu, Riley Grant, Mary T Yohannes, Zan Koenig, Yossi Farjoun, Eric Banks, Stacey Donnelly, Stacey Gabriel, Namrata Gupta, Steven Ferriera, Charlotte Tolonen, Sam Novod, Louis Bergelson, David Roazen, Valentin Ruano-Rubio, Miguel Covarrubias, Christopher Llanwarne, Nikelle Petrillo, Gordon Wade, Thibault Jeandet, Ruchi Munshi, Kathleen Tibbetts, Anne O’Donnell-Luria, Matthew Solomonson, Cotton Seed, Alicia R Martin, Michael E Talkowski, Heidi L Rehm, Mark J Daly, Grace Tiao, Benjamin M Neale, Daniel G MacArthur, Konrad J Karczewski†
2023
Nature Genetics
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture
International League Against Epilepsy Consortium on Complex Epilepsies (Chen S*, co-first author)
2022
Genome Research
A full-proteome, interaction-specific characterization of mutational hotspots across human cancers
Siwei Chen, Yuan Liu, Yingying Zhang, Shayne D Wierbowski, Steven M Lipkin, Xiaomu Wei, Haiyuan Yu
2020
Molecular Autism
De novo missense variants disrupting protein–protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types
Siwei Chen*, Jiebiao Wang*, Ercument Cicek, Kathryn Roeder†, Haiyuan Yu†, Bernie Devlin†
2018
Nature Genetics
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders
Siwei Chen*, Robert Fragoza*, Lambertus Klei, Yuan Liu, Jiebiao Wang, Kathryn Roeder†, Bernie Devlin†, Haiyuan Yu†